| Title | 2014년 경기지역에서 발생한 해외유입 홍역 바이러스의 분자역학적 특성 분석 | ||
| Author | 윤희정, 박포현, 황선일, 허정원, 남수정, 용금찬, and 윤미혜 | ||
| Address | 경기도보건환경연구원 바이러스팀 | ||
| Bibliography | Korean Journal of Microbiology, 53(1),1-8, 2017 | ||
| DOI | https://doi.org/10.7845/kjm.2017.6061 | ||
| Key Words | disease, epidemiology, genotype B3, measles virus, prevention | ||
| Abstract | Measles virus is a highly contagious, exanthematic virus, preventable by the use of an effective live-attenuated vaccine. However, measles virus remains endemic in many area of the world causing nearly 200,000 deaths per year and still a major cause of child mortality, mostly in developing countries. In March 2014, Republic of Korea was certified as a ‘national measles elimination’ by the WHO as a result of a high-quality case-based surveillance system and population immunity, which was achieved by a high vaccination rate (>95.0% since 1996). But, since the beginning of 2014, the Gyeonggi province has experienced a resurgence of measles cases. In this study, we investigated the characteristics of measles viruses isolated from confirmed measles in Gyeonggi province during January 1, 2014 ~ July 31, 2014, 60 isolates were obtained from 72 confirmed measles specimens. Genotypic distributions and genetic diversities of isolated measles virus were analyzed by sequencing of nucleoprotein (N) gene. 58 (96.7%) imported cases were identified. The predominant genotype was B3, which reflects the circulating measles virus in adjacent countries. The sequences of nucleoprotein (N) gene of isolated MeV were showed that the strains characterized showed the highest degree of identity (99%) with the Philippine related strains in 2013–2014. Therefore, infected traveler returning from the Philippines transmitted secondary infection in Korea. | ||
| Download PDF | 01_HM2016-061.pdf | ||