Title Molecular Cloning and Nucleotide sequence of Schizosaccharomyces pombe Homologue of the Receptor for Activated Protein Kinase C Gene
Author Park, Seung Kiel · Yoo, Hyang Sook *
Address Biomedical Research Group, Korea Research Institute of Bioscience and Biotechnology, Korea Institute of Science and Technology
Bibliography Journal of Microbiology, 33(2),128-131, 1995,
Key Words receptor of activated protein kinase C, protein kinase C, trimeric G protein beta subunit, Schizosaccharomuces pombe
Abstract Using differential hybridization, we selected the prk gene fortuitously from Schizosaccharomyces pombe homologous to RACK1 of rat which encodes the receptor for activated protein kinase C. The cDNA sequence of prk was determined and its deduced amino acid sequence was 76% homologous to RACK1 and had the feature of trimeric G protein beta subunit. The specific amino acid sequences required for the protein kinase C binding were also present in Prk as in the case of RACK1 protein. From these similarities, we suggest that the Prk is protein kinase C binding protein of S. prombe. The involvement of Prk in signal transduction mediated by protein kinase C remained to be studied.
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