Title Production of a monoclonal antibody and ultrastructure of the sporozoite of cryptosporidium parvum
Author Choi, Young Sook¹ · Lee, Sung Tae² · Cho, Myung Hwan *
Address Department of Biology, College of Sciences; ¹Department of clinical Pathology; ²Orthopedic Surgery, College of Medicine, Kon-Kuk University
Bibliography Journal of Microbiology, 34(4),379-383, 1996,
Key Words Cryptosporidium, AIDSm sporozoite, ultrastructure, monoclonal antibody
Abstract Cryptosporidium Parvum causes a life-threatening diarrhea in acquired immunodeficiency syndrome (AIDS) patients. The sporozoite stage of C. parvum has been known to be a target in treating cryptosporidiosis in AIDS patients as it is an extracellular stage. A sporozoite was ultrastructurally observed. It has a crescent shape with a rounded posterior end and a tapering body. The compact nucleus was located at the posterior end. A monoclonal antibody was produced, which recognized a 43 kDa of sporozoite antigens in a western blot analysis and showed the surface labeling in immunofluorescence.
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