| Title | Antimicrobial Susceptibility and Clonal Relatedness between Community- and Hospital-Acquired Methicillin-Resistant Staphylococcus aureus from Blood Cultures |
|---|---|
| Author | Sook-In Jung*1, Dong Hyeon Shin1, Kyeong Hwa Park1, and Jong Hee Shin2 |
| Address | 1Departments of Infectious Diseases Chonnam National University Medical School, Gwangju, Republic of Korea, 2Departments of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea |
| Bibliography | Journal of Microbiology, 44(3),336-343, 2006, |
| DOI | |
| Key Words | MRSA, community-acquired, antimicrobial resistance, clonal relationship |
| Abstract | We compared the antimicrobial resistance and clonal relationships among the communityacquired (CA) and hospital-acquired (HA) methicillin-resistant Staphylococcus aureus (MRSA) strains that were isolated from blood cultures in a university hospital over a 4-year period. A total of 131 MRSA isolates, including 28 CA-MRSA and 103 HA-MRSA strains, were identified; antimicrobial susceptibility testing indicated that the CA-MRSA isolates were more susceptible to erythromycin (21% vs 6%; P=0.02), clindamycin (46% vs 12%; P<0.01), ciprofloxacin (43% vs 11%; P<0.01), and gentamicin (43% vs 6%; P<0.01) than were the HA-MRSA isolates. Pulsed-field gel electrophoresis (PFGE) typing and antimicrobial resistance profiles separated the 20 CA-MRSA isolates into 14 and 10 different patterns, respectively, and the 53 HA-MRSA isolates were separated into 24 and 7 different patterns, respectively. Twenty-one (40%) of the 53 HA-MRSA isolates belonged to two predominant PFGE types, and most of them showed multi-drug resistant patterns. Four (20%) of the 20 CA-MRSA and 10 (19%) of the 53 HA-MRSA isolates fell into two common PFGE patterns, and each of them showed the same multi-drug resistant pattern. This study suggests that, although the CA-MRSA blood isolates showed diverse PFGE and antimicrobial resistance patterns, some of these isolates may have originated from the HA-MRSA strains. |
| Download PDF | JM2005-162.pdf |