| Title | Immunological Roles of Pasteurella multocida Toxin (PMT) Using a PMT Mutant Strain |
|---|---|
| Author | Tae Jung Kim1, Nguyen Tat Toan2, Eun Jin Jang2, Bock Gie Jung2, Jae Il Lee2, and Bong Joo Lee1* |
| Address | 1Biotheraphy Human Resources Center, Chonnam National University, Gwangju 500-757, Republic of Korea, 2College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Republic of Korea |
| Bibliography | Journal of Microbiology, 45(4),364-366, 2007, |
| DOI | |
| Key Words | knock-out, Pasteurella multocida toxin (PMT), sub-population, toxA |
| Abstract | The immunological role of the Pasteurella multocida toxin (PMT) in mice was examined using a PMT mutant strain. After a nasal inoculation, the mutant strain failed to induce interstitial pneumonia. Moreover, PMT had no significant effect on the populations of CD4+, CD8+, CD3+, and CD19+ immunocytes in blood or on the populations of CD4+ and CD8+ splenocytes (P<0.01). However, there was a significant increase in the total number of cells in the BAL samples obtained from the wild-type P. multocida-inoculated mice. On the other hand, the level of IL-1 expression decreased when the macrophages from the bronchio-alveolar lavage were stimulated with PMT. Overall, PMT appears to play some role (stimulating and/or inhibiting) in the immunological responses but further studies will be required to confirm this. |
| Download PDF | 45(4)_14.pdf |