| Title | In vitro Activity of Kaempferol Isolated from the Impatiens balsamina alone and in Combination with Erythromycin or Clindamycin against Propionibacterium acnes |
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| Author | Young-Hee Lim1*, In-Hwan Kim2, and Jung-Ju Seo3 |
| Address | 1Department of Clinical Laboratory Science, College of Health Sciences, Korea University, Seoul 136-703, Republic of Korea, 2Department of Food and Nutrition, College of Health Sciences, Korea University, Seoul 136-703, Republic of Korea, 3Hazardous Substance Research Team, Korea Basic Science Institute, Seoul 136-701, Republic of Korea |
| Bibliography | Journal of Microbiology, 45(5),473-477, 2007, |
| DOI | |
| Key Words | Propionibacterium acnes, kaempferol, erythromycin, clindamycin, checkerboard test |
| Abstract | The in vitro antibacterial activity against antibiotic-resistant Propionibacterium acnes of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin antibiotics was investigated. The antibiotic combination effect against antibiotic-resistant P. acnes was studied by checkerboard test. Kaempferol and quercetin demonstrated antibacterial activities against P. acnes. Minimum inhibitory concentrations (MICs) for both compounds were ≤32 μg/ml and ≤64 μg/ml for clindamycin-sensitive and-resistant P. acnes, respectively. The four combination formulations (kaempferol and either erythromycin or clindamycin; quercetin and either erythromycin or clindamycin) exhibited a synergic inhibition of P. acnes growth. The combination of kaempferol with quercetin showed an indifferent effect. The combination of clindamycin with kaempferol or quercetin showed a greater synergic effect than that of erythromycin with kaempferol or quercetin. Thus, these combinations demonstrated the potential to treat acne. |
| Download PDF | 45(5)_15.pdf |