| Title |
Synergistic Antibacterial Effect between Silybin and N,N’-Dicyclohexylcarbodiimide in Clinical Pseudomonas aeruginosa Isolates |
| Author |
Hyun Jun Jung and Dong Gun Lee* |
| Address |
Department of Microbiology, College of Natural Sciences, Kyungpook National University, Daegu 702-701, Republic of Korea |
| Bibliography |
Journal of Microbiology, 46(4),462-467, 2008,
|
| DOI |
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| Key Words |
silybin, antibacterial activity, MDR pump, synergistic effect, N,N′-dicyclohexylcarbodiimide |
| Abstract |
Silybin is a composition of the silymarin group as a hepatoprotective agent, and it exhibits various biological activities, including an antibacterial activity. In this study, the effects of a combination of silybin with N,N′-dicyclohexylcarbodiimide (DCCD) against clinical isolates of Pseudomonas aeruginosa were investigated. In the results of susceptibility assay, silybin showed more potent antibacterial activity in methicilin-resistant Staphylococcus aureus (MRSA) than in P. aeruginosa, but DCCD significantly increased the antibacterial activity of silybin in P. aeruginosa. The antibacterial activity of silybin was affected by the strong action of multidrug-resistant pumps rather than by a permeable disruption of lipopolysaccharide and silybin showed a remarkable synergistic activity in combination with some antibiotic agents against drug-resistant bacteria. Therefore, silybin has a potential as a combination therapeutic agent for treatment of infectious diseases by multidrug-resistant bacteria. |
