| Title |
Inhibitory Effect of Methyl Gallate and Gallic Acid on Oral Bacteria |
| Author |
Mi-Sun Kang1, Jong-Suk Oh1, In-Chol Kang2,3, Suk-Jin Hong3,4, and Choong-Ho Choi3,4* |
| Address |
1Department of Microbiology, School of Medicine, Chonnam National University, Gwangju 501-746, Republic of Korea, 2Brain Korea 21 Program, 3Dental Science Research Institute, Chonnam National University, Gwangju 500-757, Republic of Korea, 4Department of Preventive and Public Health Dentistry, Chonnam National University, Gwangju 501-746, Republic of Korea |
| Bibliography |
Journal of Microbiology, 46(6),744-750, 2008,
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| DOI |
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| Key Words |
antibacterial activity, Galla Rhois, gallic acid, methyl gallate, oral bacteria |
| Abstract |
This study examined the ability of methyl gallate (MG) and gallic acid (GA), the main compounds of gallotannins in Galla Rhois, to inhibit the proliferation of oral bacterial and the in vitro formation of Streptococcus mutans biofilms. The antimicrobial activities of these compounds were evaluated in vitro using the broth microdilution method and a beaker-wire test. Both MG and GA had inhibitory effects on the growth of cariogenic (MIC<8 mg/ml) and periodontopathic bacteria (MIC=1 mg/ml). Moreover, these compounds significantly inhibited the in vitro formation of S. mutans biofilms (MG, 1 mg/ml; GA, 4 mg/ml; P<0.05). MG was more effective in inhibiting bacterial growth and the formation of S. mutans biofilm than GA. In conclusion, MG and GA can inhibit the growth of oral pathogens and S. mutans biofilm formation, and may be used to prevent the formation of oral biofilms. |
