| Title |
Acinetobacter baumannii Outer Membrane Protein A Induces Dendritic Cell Death Through Mitochondrial Targeting |
| Author |
Jun Sik Lee, Chul Hee Choi, Jung Wook Kim, and Je Chul Lee* |
| Address |
Department of Microbiology, Kyungpook National University School of Medicine, Daegu 700-422, Republic of Korea |
| Bibliography |
Journal of Microbiology, 48(3),387-392, 2010,
|
| DOI |
|
| Key Words |
A. baumannii, dendritic cell, immunopathology, ROS |
| Abstract |
Acinetobacter baumannii outer membrane protein A (AbOmpA) is a potential virulence factor that induces epithelial cell death, but its pathologic effects on the immune system have yet to be determined. The present study investigated the pathologic events occurring in dendritic cells (DCs) exposed to a cytotoxic
concentration of AbOmpA. AbOmpA induced early-onset apoptosis and delayed-onset necrosis in DCs. AbOmpA targeted the mitochondria and induced the production of reactive oxygen species (ROS). ROS were directly responsible for both apoptosis and necrosis of AbOmpA-treated DCs. These results demonstrate
that the AbOmpA secreted from A. baumannii induces DC death, which may impair T cell biology to induce adaptive immune responses against A. baumannii. |
