Title Providencia Isolates Carrying blaPER-1 and blaVIM-2 Genes: Biofilm-Forming Capacity and Biofilm Inhibitory Concentrations for Carbapenem Antibiotics
Author Jungmin Kim, Shukho Kim, Hee Woo Lee, Sung Min Kim, and Sung Yong Seol*
Address Department of Microbiology, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea
Bibliography Journal of Microbiology, 49(3),512-515, 2011,
Key Words multi-drug resistant Providencia, biofilms, PER-1, MBIC, MBEC
Abstract Multidrug-resistant clinical isolates of Providencia carrying blaPER-1 and blaVIM-2 were evaluated for the abilities to form biofilm and high biofilm forming capacity was demonstrated in them. Minimum biofilm inhibitory concentrations (MBICs), minimum biofilm eradication concentrations (MBECs), and minimum inhibitory concentrations (MICs) for imipenem and meropenem were also determined. In all tested strains, the MBICs were higher than the MICs for both drugs. Interestingly, the MBICs and the MBEC50 for meropenem were lower than those for imipenem in the isolates producing high amounts of biofilm, suggesting that meropenem is superior to imipenem in the growth inhibition and eradication of biofilm forming Providencia strains.