| Title |
Neutralization Potential of the Plasma of HIV-1 Infected Indian Patients in the Context of Anti-V3 Antibody Content and Antiretroviral Theraphy |
| Author |
Alok Kumar Choudhary1, Raiees Andrabi1, Somi Sankaran Prakash1, Rajesh Kumar1, Shubhasree Dutta Choudhury Choudhury1, Naveet Wig2, Ashutosh Biswas2, Anjali Hazarika3, and Kalpana Luthra1* |
| Address |
1Department of Biochemistry, CN Centre, All India Institute of Medical Sciences, 110029, New Delhi, India, 2Department of Medicine, CN Centre, All India Institute of Medical Sciences, 110029, New Delhi, India, 3Department of Blood Bank, CN Centre, All India Institute of Medical Sciences, 110029, New Delhi, India |
| Bibliography |
Journal of Microbiology, 50(1),149-154, 2012,
|
| DOI |
|
| Key Words |
HIV-1, India, neutralizing antibodies, anti-V3 antibodies, antiretroviral therapy |
| Abstract |
We assessed the anti-V3 antibody content and viral neutralization
potential of the plasma of 63 HIV-1-infected patients
(antiretroviral naïve=39, treated=24) against four primary
isolates (PIs) of clade C and a tier 1 clade B isolate SF162.
Depletion and inhibition of anti-V3 antibodies in the plasma
of five patients with high titers of anti-V3 antibodies led to
modest change in the neutralization percentage against two
PIs (range 0–21%). The plasma of antiretroviral-treated
patients exhibited higher neutralization potential than that
of the drug-naïve plasmas against the four PIs tested which
was further evidenced by a follow-up study. |
