| Title |
Effect of Lactobacillus reuteri on the Proliferation of Propionibacterium acnes and Staphylococcus epidermidis |
| Author |
Mi-Sun Kang1, Jong-Suk Oh1, Seok-Woo Lee2,3, Hoi-Soon Lim3, Nam-Ki Choi2,4, and Seon-Mi Kim2,4* |
| Address |
1Department of Microbiology, School of Medicine, Chonnam National University, Gwangju 501-746, Republic of Korea , 2Dental Science Research Institute, Chonnam National University, Gwangju 500-757, Republic of Korea, 3Department of Dental Education, Chonnam National University, Gwangju 500-757, Republic of Korea, 4Department of Pediatric Dentistry, Chonnam National University, Gwangju 500-757, Republic of Korea |
| Bibliography |
Journal of Microbiology, 50(1),137-142, 2012,
|
| DOI |
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| Key Words |
Lactobacillus reuteri, Propionibacterium acnes, Staphylococcus epidermidis, antibacterial |
| Abstract |
While it is generally accepted that Propionibacterium acnes
is involved in the development of acne, other bacteria including
Staphylococcus epidermidis have also been isolated
from the acne lesion. The interaction between Lactobacillus
reuteri, a probiotic bacterium, and acnegenic bacteria is
unclear. This study examined the effects of L. reuteri on the
proliferation of P. acnes and S. epidermidis. Human-derived
L. reuteri strains (KCTC 3594 and KCTC 3678) and rat-derived
L. reuteri KCTC 3679 were used. All strains exhibited
significant inhibitory effects on the growth of P. acnes and
S. epidermidis. The proliferation of P. acnes was decreased
by 2-log scales after incubation with L. reuteri for 24 h. In
addition, the proliferation of S. epidermidis was decreased
by 3-log scales after incubation with L. reuteri for 24 h,
whereas the growth of L. reuteri was unaffected by P. acnes
or S. epidermidis. Among the L. reuteri strains examined, L.
reuteri KCTC 3679 had the strongest inhibitory effect on
the growth of P. acnes and S. epidermidis, followed by L.
reuteri KCTC 3594 and L. reuteri KCTC 3678. Interestingly,
reuterin, an antimicrobial factor, was produced only by L.
reuteri KCTC 3594. The most pronounced the antibacterial
activities of L. reuteri were attributed to the production of
organic acids. Overall, these results suggest that L. reuteri
may be a useful probiotic agent to control the growth of
bacteria involved in acne inflammation and prevent acne. |
