Title NOTE] Envelope Diversity, Characteristics of V3 Region and Predicted Co-Receptor Usage of Human Immunodeficiency Viruses Infecting North Indians
Author Raiees Andrabi1, Rajesh Kumar1, Manju Bala2, Ambili Nair1, Prakash SS1, Vandana Kushwaha1, and Kalpana Luthra1*
Address 1Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India, 2Regional STD Teaching Training & Research Centre, Safdarjung Hospital, New Delhi, India
Bibliography Journal of Microbiology, 50(5),869-873, 2012,
Key Words HIV-1, subtypes, envelope glycoprotein, variable regions, co-receptor usage
Abstract Subtypes of human immunodeficiency virus type 1 circulating in 21 north Indian patients were characterized based on the partial sequence of the gp120 envelope protein. A majority of viruses (85.7%, 18/21) were subtype C, while 14.3% (3/21) were subtype A. Sequence analysis revealed that the V3 region was highly conserved compared with V4 and V5. The predicted use of co-receptors indicated exclusive usage of R5, except for two subtype A viruses (AIIMS279 and AIIMS281). Our results demonstrate conservation within the V3 loop of subtype C viruses, and suggest the emergence of non-clade C viruses in the north Indian population.