Title NOTE] Antifungal Activity of Extracellular Hydrolases Produced by Autolysing Aspergillus nidulans Cultures
Author Melinda Szilágyi1, Fruzsina Anton1, Katalin Forgács1, Jae-Hyuk Yu2, István Pócsi1, and Tamás Emri1*
Address 1Department of Microbial Biotechnology and Cell Biology, Faculty of Science and Technology, University of Debrecen, Debrecen, Hungary, 2Departments of Bacteriology and Genetics, University of Wisconsin, Madison, WI, USA
Bibliography Journal of Microbiology, 50(5),849-854, 2012,
Key Words antifungal activity, A. nidulans, chitinase, β-1,3-glucanase, proteinase
Abstract Carbon-starving Aspergillus nidulans cultures produce high activities of versatile hydrolytic enzymes and, among these, ChiB endochitinase and EngA β-1,3-endoglucanase showed significant antifungal activity against various fungal species. Double deletion of engA and chiB diminished the antifungal activity of the fermentation broths and increased conidiogenesis and long-term viability of A. nidulans, but decreased the growth rate on culture media containing weak carbon sources. Production of ChiB and EngA can influence fungal communities either directly due to their antifungal properties or indirectly through their effects on vegetative growth. Our data suggest saprophytic fungi as promising future candidates to develop novel biocontrol technologies.