Title Cyclic Dipeptides from Lactic Acid Bacteria Inhibit the Proliferation of Pathogenic Fungi
Author Min-Kyu Kwak1, Rui Liu1, Min-Kyu Kim1, Dohyun Moon2, Andrew HyoungJin Kim1, Sung-Hyun Song1, and Sa-Ouk Kang1*
Address 1Laboratory of Biophysics, School of Biological Sciences, and Institute of Microbiology, Seoul National University, Seoul 151-747, Republic of Korea, 2Beamline Division, X-ray Research II Team at Pohang Accelerator Laboratory, POSTECH, Pohang 790-784, Republic of Korea
Bibliography Journal of Microbiology, 52(1),64–70, 2014,
DOI 10.1007/s12275-014-3520-7
Key Words Lactobacillus plantarum LBP-K10, culture filtrate, cis-cyclo(L-Val-L-Pro), cis-cyclo(L-Phe-L-Pro), Ganoderma boninense, Candida albicans
Abstract Lactobacillus plantarum LBP-K10 was identified to be the most potent antifungal strain from Korean traditional fermented vegetables. The culture filtrate of this strain showed remarkable antifungal activity against Ganoderma boninense. Five fractions from the culture filtrate were observed to have an inhibitory effect against G. boninense. Also, the electron ionization and chemical ionization indicated that these compounds might be cyclic dipeptides. Of the five active fractions, two fractions showed the most significant anti-Ganoderma activity, and one of these fractions inhibited the growth of Candida albicans. These compounds were identified to be cis-cyclo(L-Val-L-Pro) and cis-cyclo(L-Phe-L-Pro), as confirmed by X-ray crystallography.