Title REVIEW] Enterococcus Infection Biology: Lessons from Invertebrate Host Models
Author Grace J. Yuen1,2 and Frederick M. Ausubel1,3*
Address 1Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA, 2Program in Immunology, Harvard Medical School, Boston, MA 02115, USA , 3Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Bibliography Journal of Microbiology, 52(3),200-210, 2014,
DOI 10.1007/s12275-014-4011-6
Key Words Enterococcus, innate immunity, Caenorhabditis elegans, Galleria mellonella
Abstract The enterococci are commensals of the gastrointestinal tract of many metazoans, from insects to humans. While they normally do not cause disease in the intestine, they can become pathogenic when they infect sites outside of the gut. Recently, the enterococci have become important nosocomial pathogens, with the majority of human enterococcal infections caused by two species, Enterococcus faecalis and Enterococcus faecium. Studies using invertebrate infection models have revealed insights into the biology of enterococcal infections, as well as general principles underlying host innate immune defense. This review highlights recent findings on Enterococcus infection biology from two invertebrate infection models, the greater wax moth Galleria mellonella and the free-living bacteriovorous nematode Caenorhabditis elegans.