Title |
REVIEW] Production of cross-kingdom oxylipins by pathogenic fungi: An update on their role in development and pathogenicity |
Author |
Gregory J. Fischer1 and Nancy P. Keller2* |
Address |
1Department of Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA , 2Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA |
Bibliography |
Journal of Microbiology, 54(3),254-264, 2016,
|
DOI |
10.1007/s12275-016-5620-z
|
Key Words |
oxylipins, fungi, microbial interactions |
Abstract |
Oxylipins are a class of molecules derived from the incorporation
of oxygen into polyunsaturated fatty acid substrates
through the action of oxygenases. While extensively investigated
in the context of mammalian immune responses, over
the last decade it has become apparent that oxylipins are a
common means of communication among and between plants,
animals, and fungi to control development and alter hostmicrobe
interactions. In fungi, some oxylipins are derived nonenzymatically
while others are produced by lipoxygenases,
cyclooxygenases, and monooxygenases with homology to
plant and human enzymes. Recent investigations of numerous
plant and human fungal pathogens have revealed oxylipins
to be involved in the establishment and progression of disease.
This review highlights oxylipin production by pathogenic
fungi and their role in fungal development and pathogen/
host interactions. |