| Title | MINIREVIEW] Multilayered regulations of RIG-I in the anti-viral signaling pathway |
|---|---|
| Author | Nari Kim*, Hesung Now, Nhung T.H. Nguyen, and Joo-Yeon Yoo* |
| Address | Department of Life Sciences, Pohang University of Science and Technology, Pohang 37673, Republic of Korea |
| Bibliography | Journal of Microbiology, 54(9),583-587, 2016, |
| DOI | 10.1007/s12275-016-6322-2 |
| Key Words | RIG-I, antiviral signaling, RNA virus, post-translational modification, protein-protein interaction |
| Abstract | RIG-I is a cytosolic receptor recognizing virus-specific RNA structures and initiates an antiviral signaling that induces the production of interferons and proinflammatory cytokines. Because inappropriate RIG-I signaling affects either viral clearance or immune toxicity, multiple regulations of RIG-I have been investigated since its discovery as the viral RNA detector. In this review, we describe the recent progress in research on the regulation of RIG-I activity or abundance. Specifically, we focus on the mechanism that modulates RIGI- dependent antiviral response through post-translational modifications of or protein-protein interactions with RIG-I. |