| Title | MINIREVIEW] Global transcriptional regulator TrmB family members in prokaryotes |
|---|---|
| Author | Minwook Kim1, Soyoung Park1#, and Sung-Jae Lee1,2* |
| Address | 1Department of Biology, Kyung Hee University, Seoul 02447, Republic of Korea, 2Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea, #Present address: Department of Biophysics and Chemical Biology, Seoul National University, Seoul 08826, Republic of Korea |
| Bibliography | Journal of Microbiology, 54(10),639-645, 2016, |
| DOI | 10.1007/s12275-016-6362-7 |
| Key Words | TrmB family members, global transcriptional regulator, sugar-binding motif, extremophile, prokaryote |
| Abstract | Members of the TrmB family act as global transcriptional regulators for the activation or repression of sugar ABC transporters and central sugar metabolic pathways, including glycolytic, gluconeogenic, and other metabolic pathways, and also as chromosomal stabilizers in archaea. As a relatively newly classified transcriptional regulator family, there is limited experimental evidence for their role in Thermococcales, halophilic archaeon Halobacterium salinarum NRC1, and crenarchaea Sulfolobus strains, despite being one of the extending protein families in archaea. Recently, the protein structures of Pyrococcus furiosus TrmB and TrmBL2 were solved, and the transcriptomic data uncovered by microarray and ChIP-Seq were published. In the present review, recent evidence of the functional roles of TrmB family members in archaea is explained and extended to bacteria. |