| Title | MINIREVIEW] The therapeutic applications of antimicrobial peptides (AMPs): a patent review |
|---|---|
| Author | Hee-Kyoung Kang1, Cheolmin Kim2, Chang Ho Seo2, and Yoonkyung Park1,3* |
| Address | 1Department of Biomedical Sciences, Chosun University, Gwangju 61452, Republic of Korea, 2Department of Bioinformatics, Kongju National University, Kongju 32588, Republic of Korea, 3Research Center for Proteinaceous Materials, Chosun University, Gwangju 61452, Republic of Korea |
| Bibliography | Journal of Microbiology, 55(1),1-12, 2017, |
| DOI | 10.1007/s12275-017-6452-1 |
| Key Words | antimicrobial peptide, therapies, drug candidate, pathogenic bacteria |
| Abstract | Antimicrobial peptides (AMPs) are small molecules with a broad spectrum of antibiotic activities against bacteria, yeasts, fungi, and viruses and cytotoxic activity on cancer cells, in addition to anti-inflammatory and immunomodulatory activities. Therefore, AMPs have garnered interest as novel therapeutic agents. Because of the rapid increase in drug-resistant pathogenic microorganisms, AMPs from synthetic and natural sources have been developed using alternative antimicrobial strategies. This article presents a broad analysis of patents referring to the therapeutic applications of AMPs since 2009. The review focuses on the universal trends in the effective design, mechanism, and biological evolution of AMPs. |