Title |
MINIREVIEW] Dengue and Zika viruses: lessons learned from the similarities between these Aedes mosquito-vectored arboviruses |
Author |
San Suwanmanee and Natthanej Luplertlop* |
Address |
Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand |
Bibliography |
Journal of Microbiology, 55(2),81-89, 2017,
|
DOI |
10.1007/s12275-017-6494-4
|
Key Words |
Dengue virus, Zika virus, Aedes mosquito, arboviruses,
flavivirus, microcephaly |
Abstract |
The currently spreading arbovirus epidemic is having a severe
impact on human health worldwide. The two most common
flaviviruses, dengue virus (DENV) and Zika virus (ZIKV), are
transmitted through the same viral vector, Aedes spp. mosquitoes.
Since the discovery of DENV in 1943, this virus has
been reported to cause around 390 million human infections
per year, approximately 500,000 of which require hospitalization
and over 20,000 of which are lethal. The present
DENV epidemic is primarily concentrated in Southeast Asia.
ZIKV, which was discovered in 1952, is another important
arthropod-borne flavivirus. The neurotropic role of ZIKV
has been reported in infected newborns with microcephaly
and in adults with Guillain-Barre syndrome. Despite DENV
and ZIKV sharing the same viral vector, their complex pathogenic
natures are poorly understood, and the infections they
cause do not have specific treatments or effective vaccines.
Therefore, this review will describe what is currently known
about the clinical characteristics, pathogenesis mechanisms,
and transmission of these two viruses. Better understanding
of the interrelationships between DENV and ZIKV will provide
a useful perspective for developing an effective strategy
for controlling both viruses in the future. |