Title [Minireview] Antibiofilm agents: A new perspective for antimicrobial strategy
Author Xi-Hui Li and Joon-Hee Lee*
Address Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea
Bibliography Journal of Microbiology, 55(10),753–766, 2017,
DOI 10.1007/s12275-017-7274-x
Key Words biofilm, antibiofilm agent
Abstract Biofilms are complex microbial architectures that attach to surfaces and encase microorganisms in a matrix composed of self-produced hydrated extracellular polymeric substances (EPSs). In biofilms, microorganisms become much more resistant to antimicrobial treatments, harsh environmental conditions, and host immunity. Biofilm formation by microbial pathogens greatly enhances survival in hosts and causes chronic infections that result in persistent inflammation and tissue damages. Currently, it is believed over 80% of chronic infectious diseases are mediated by biofilms, and it is known that conventional antibiotic medications are inadequate at eradicating these biofilm-mediated infections. This situation demands new strategies for biofilm-associated infections, and currently, researchers focus on the development of antibiofilm agents that are specific to biofilms, but are nontoxic, because it is believed that this prevents the development of drug resistance. Here, we review the most promising antibiofilm agents undergoing intensive research and development.