Title |
REVIEW] Intestinal microbiota and the immune system in metabolic diseases |
Author |
Panida Sittipo1, Stefani Lobionda1, Yun Kyung Lee1*, and Craig L. Maynard2* |
Address |
1Soonchunhyang Institute of Medi-Bio Science, Soonchunhyang University, Cheonan 31151, Republic of Korea, 2Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA |
Bibliography |
Journal of Microbiology, 56(3),154-162, 2018,
|
DOI |
10.1007/s12275-018-7548-y
|
Key Words |
dysbiosis, intestinal microbiota, intestinal barrier,
immune system, metabolic disease |
Abstract |
The intestinal microbiota is comprised of millions of microorganisms
that reside in the gastrointestinal tract and consistently
interact with the host. Host factors such as diet and
disease status affect the composition of the microbiota, while
the microbiota itself produces metabolites that can further
manipulate host physiology. Dysbiosis of the intestinal microbiota
has been characterized in patients with certain metabolic
diseases, some of which involve damage to the host
intestinal epithelial barrier and alterations in the immune
system. In this review, we will discuss the consequences of dietdependent
bacterial dysbiosis in the gastrointestinal tract, and
how the associated interaction with epithelial and immune
cells impacts metabolic diseases. |