Title |
REVIEW] Mind-altering with the gut: Modulation of the gut-brain axis with probiotics |
Author |
Namhee Kim, Misun Yun, Young Joon Oh, and Hak-Jong Choi* |
Address |
Microbiology and Functionality Research Group, World Institute of Kimchi, Gwangju 61755, Republic of Korea |
Bibliography |
Journal of Microbiology, 56(3),172–182, 2018,
|
DOI |
10.1007/s12275-018-8032-4
|
Key Words |
probiotics, gut microbiota, nervous system, gutbrain
axis, gut dysbiosis, neurological disorders |
Abstract |
It is increasingly evident that bidirectional interactions exist
among the gastrointestinal tract, the enteric nervous system,
and the central nervous system. Recent preclinical and clinical
trials have shown that gut microbiota plays an important role
in these gut-brain interactions. Furthermore, alterations in gut
microbiota composition may be associated with pathogenesis
of various neurological disorders, including stress, autism, depression,
Parkinson’s disease, and Alzheimer’s disease. Therefore,
the concepts of the microbiota-gut-brain axis is emerging.
Here, we review the role of gut microbiota in bidirectional
interactions between the gut and the brain, including
neural, immune-mediated, and metabolic mechanisms. We
highlight recent advances in the understanding of probiotic
modulation of neurological and neuropsychiatric disorders
via the gut-brain axis. |