Title |
[MINIREVIEW] Interdependence between iron acquisition and biofilm formation in Pseudomonas aeruginosa |
Author |
Donghoon Kang and Natalia V. Kirienko* |
Address |
Department of Biosciences, Rice University, Houston, USA |
Bibliography |
Journal of Microbiology, 56(7),449–457, 2018,
|
DOI |
10.1007/s12275-018-8114-3
|
Key Words |
iron acquisition, biofilm, nutritional immunity,
siderophore, exopolysaccharides, Pseudomonas aeruginosa |
Abstract |
Bacterial biofilms remain a persistent threat to human healthcare
due to their role in the development of antimicrobial
resistance. To combat multi-drug resistant pathogens, it is
crucial to enhance our understanding of not only the regulation
of biofilm formation, but also its contribution to bacterial
virulence. Iron acquisition lies at the crux of these two
subjects. In this review, we discuss the role of iron acquisition
in biofilm formation and how hosts impede this mechanism
to defend against pathogens. We also discuss recent findings
that suggest that biofilm formation can also have the reciprocal
effect, influencing siderophore production and iron
sequestration. |