Title |
A comprehensive review of SARS-CoV-2 genetic mutations and lessons from animal coronavirus recombination in one health perspective |
Author |
Woonsung Na1, Hyoungjoon Moon2, and Daesub Song3* |
Address |
1College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea, 2College of Healthcare & Biotechnology, Semyung University, Jecheon 27136, Republic of Korea, 3College of Pharmacy, Korea University, Sejong 30019, Republic of Korea |
Bibliography |
Journal of Microbiology, 59(3),332–340, 2021,
|
DOI |
10.1007/s12275-021-0660-4
|
Key Words |
coronavirus disease 2019, genetic mutations, animal
coronavirus, pandemic |
Abstract |
SARS-CoV-2 was originated from zoonotic coronaviruses
and confirmed as a novel beta-coronavirus, which causes serious
respiratory illness such as pneumonia and lung failure,
COVID-19. In this review, we describe the genetic characteristics
of SARS-CoV-2, including types of mutation, and
molecular epidemiology, highlighting its key difference from
animal coronaviruses. We further summarized the current
knowledge on clinical, genetic, and pathological features of
several animal coronaviruses and compared them with SARSCoV-
2, as well as recent evidences of interspecies transmission
and recombination of animal coronaviruses to provide a better
understanding of SARS-CoV-2 infection in One Health
perspectives. We also discuss the potential wildlife hosts and
zoonotic origin of this emerging virus in detail, that may help
mitigate the spread and damages caused by the disease. |