Title |
Dynamic colonization of gut microbiota and its influencing factors among the breast-feeding infants during the first two years of life |
Author |
Ping Li1, Xuelian Chang1, Xiaoyu Chen1, Tiantian Tang1, Yajing Liu2, Yu Shang3*, and Kemin Qi1* |
Address |
1Laboratory of Nutrition and Development, Key Laboratory of Major Diseases in Children Ministry of Education, Beijing Pediatric Research Institution, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, P. R. China, 2Child Health-care Department, Shunyi District Maternal and Child Health Care Hospital of Beijing, Beijing 101300, P. R. China, 3Child Health-care Department, Chaoyang District Maternal and Child Health Care Hospital of Beijing, Beijing 100021, P. R. China |
Bibliography |
Journal of Microbiology, 60(8),780-794, 2022,
|
DOI |
10.1007/s12275-022-1641-y
|
Key Words |
dynamic maturation, gut microbiota, milk microbiota,
body mass index, faeces |
Abstract |
The maturation of infant gut microbiota has lifelong implications
on health, which has been proposed as the major events
during the first year of life. However, little is known about
their dynamic colonization and influencing elements among
the first two-year infancy as well as into the adulthood. So
based on the 16S rRNA sequencing data among 30 healthy
breast-feeding mother-infant pairs with normal ranges of
growth and development indicators from birth to two years
old, the dynamic colonization of gut microbiota and its influencing
factors were discussed using this birth cohort. Among
these, we identified that the diversity of gut microbiota was
significantly increased from six-month to two-year subgroups.
The significantly dynamic trends of gut microbiota at the phylum
(genus) level were that the percents of Firmicutes (Faecalibacterium,
Blautia, Enterococcus, Subdoligranulum, Agathobacter,
unidentified_Erysipelotrichaceae, Staphylococcus,
unidentified_Ruminococcaceae, and Fusicatenibacter), Bacteroidetes
and Verrucomicrobia were increased, while Actinobacteria
(Bifidobacterium) and Proteobacteria (unidentified-
Enterobacteriaceae and Klebsiella) were decreased with
the increased ages from six months to two years old, which
might simultaneously modulate the host pathways, such as
the higher percents of chemoheterotrophy and fermentation,
and lower percentages of nitrate_reduction, aerobic_chemoheterotrophy
and so on. Furthermore, there were significant
associations between maternal (milk microbiota, pre-pregnancy
BMI, BMI increment during the pregnancy)/infant
characteristics (BMI at birth and BMI gain), and the compositions
of gut microbiota. However, no differences of gut
microbiota were shown between the different sex and productive
mode subgroups. Overall, the colonization of gut microbiota
is significantly matured into the adulthood with the
increased ages to two-years old and regulated by the above
maternal/infant characteristics, which will provide a new direction
for the host-gut microbiota interplay during the first
two years of life. |