Title Gut Lactobacillus and Probiotics Lactobacillus lactis/rhamnosis Ameliorate Liver Fibrosis in Prevention and Treatment
Author Sung Min Won1, Na Young Lee1, Ki‑Kwang Oh1, Haripriya Gupta1, Satya Priya Sharma1, Kyung Hwan Kim2, Byoung Kook Kim2, Hyun Chae Joung2, Jin Ju Jeong1, Raja Ganesan1, Sang Hak Han3, Sang Jun Yoon1, Dong Joon Kim1, and Ki Tae Suk1*
Address 1Institute for Liver and Digestive Diseases, Hallym University, Chuncheon 24252, Republic of Korea, 2Chong Kun Dang Bio Research Institute, Ansan, Republic of Korea, 3Department of Pathology, Hallym University College of Medicine, Chuncheon 24252, Republic of Korea
Bibliography Journal of Microbiology, 61(2),245-257, 2023,
DOI 10.1007/s12275-023-00014-y
Key Words Liver fibrosis · Lactobacillus lactis · Lactobacillus rhamnosus · Probiotics · Gut microbiome
Abstract The progression and exacerbation of liver fibrosis are closely related to the gut microbiome. It is hypothesized that some probiotics may slow the progression of liver fibrosis. In human stool analysis [healthy group (n = 44) and cirrhosis group (n = 18)], difference in Lactobacillus genus between healthy group and cirrhosis group was observed. Based on human data, preventive and therapeutic effect of probiotics Lactobacillus lactis and L. rhamnosus was evaluated by using four mice fibrosis models. L. lactis and L. rhamnosus were supplied to 3,5-diethoxycarbonyl-1,4-dihydrocollidine or carbon tetrachloride-induced liver fibrosis C57BL/6 mouse model. Serum biochemical measurements, tissue staining, and mRNA expression in the liver were evaluated. The microbiome was analyzed in mouse cecal contents. In the mouse model, the effects of Lactobacillus in preventing and treating liver fibrosis were different for each microbe species. In case of L. lactis, all models showed preventive and therapeutic effects against liver fibrosis. In microbiome analysis in mouse models administered Lactobacillus, migration and changes in the ratio and composition of the gut microbial community were confirmed. L. lactis and L. rhamnosus showed preventive and therapeutic effects on the progression of liver fibrosis, suggesting that Lactobacillus intake may be a useful strategy for prevention and treatment.