| Title | Mycobacterial Regulatory Systems Involved in the Regulation of Gene Expression Under Respiration‑Inhibitory Conditions |
|---|---|
| Author | Yuna Oh1, Ha‑Na Lee2, Eon‑Min Ko3, Ji‑A Jeong3, Sae Woong Park2, and Jeong‑Il Oh1,4* |
| Address | 1Department of Integrated Biological Science, Pusan National University, Busan 46241, Republic of Korea, 2Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA, 3Division of Bacterial Disease Research, Center for Infectious Disease Research, Korea Disease Control and Prevention Agency, National Institute of Infectious Diseases, National Institute of Health, Osong 28159, Republic of Korea, 4Microbiological Resource Research Institute, Pusan National University, Busan 46241, Republic of Korea |
| Bibliography | Journal of Microbiology, 61(3),297-315, 2023, |
| DOI | 10.1007/s12275-023-00026-8 |
| Key Words | cAMP receptor protein · DevSR · DosSR · MprBA · Mycobacterium · SigB · SigE · SigF · Stringent response |
| Abstract | Mycobacterium tuberculosis is the causative agent of tuberculosis. M. tuberculosis can survive in a dormant state within the granuloma, avoiding the host-mounting immune attack. M. tuberculosis bacilli in this state show increased tolerance to antibiotics and stress conditions, and thus the transition of M. tuberculosis to the nonreplicating dormant state acts as an obstacle to tuberculosis treatment. M. tuberculosis in the granuloma encounters hostile environments such as hypoxia, nitric oxide, reactive oxygen species, low pH, and nutrient deprivation, etc., which are expected to inhibit respiration of M. tuberculosis. To adapt to and survive in respiration-inhibitory conditions, it is required for M. tuberculosis to reprogram its metabolism and physiology. In order to get clues to the mechanism underlying the entry of M. tuberculosis to the dormant state, it is important to understand the mycobacterial regulatory systems that are involved in the regulation of gene expression in response to respiration inhibition. In this review, we briefly summarize the information regarding the regulatory systems implicated in upregulation of gene expression in mycobacteria exposed to respiration-inhibitory conditions. The regulatory systems covered in this review encompass the DosSR (DevSR) two-component system, SigF partner switching system, MprBA-SigE-SigB signaling pathway, cAMP receptor protein, and stringent response. |